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Mouse Anti-Human CD49b-PE (HAS-4)

Cat. No.:
PE Anti-Human CD49b antibody for use in flow cytometry assays.
Size Price (USD) Quantity
100 tests $248.00
More Information
Clone HAS-4
Isotype Mouse IgG2aκ
Isotype Control Mouse IgG2a-PE (HOPC-1)
Specificity Human CD49b
Alternative Names Integrin α2, VLA-2α, very late antigen-2
Description CD49b, a member of the integrin family of extracellular matrix and cell adhesion molecules, is the integrin α2 chain. CD49b associates noncovalently with CD29, the integrin β1 subunit, to form the heterodimer integrin α2β1 that binds laminin and collagen. It is expressed on B and T lymphocytes, NK cells, monocytes, platelets, fibroblasts, and long-term cultured T cells. CD49b/CD29 mediates the Mg++-dependent adhesion of platelets to collagen. It may also be utilized by fibroblasts for the reorganization of the collagen matrix during wound healing.
Immunogen Human keratinocytes
Conjugate PE (R-phycoerythrin)
Buffer Formulation Phosphate buffered saline containing < 0.1% sodium azide and a stabilizer
Clonality Monoclonal
Concentration Lot specific
Volume 1.0 mL
Recommended Storage 2-8°C; Avoid exposure to light; Do not freeze
Applications Flow Cytometry – Quality tested 6,7
Immunohistochemistry-Frozen Sections – Reported in literature 2,3
Immunocytochemistry – Reported in literature 4
Immunoprecipitation – Reported in literature 1,2,6
Blocking – Reported in literature 5

RRID Number AB_2796792
Gene ID 3673 (Human)
Gene ID Symbol ITGA2 (Human)
Gene ID Aliases BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2
UniProt ID P17301 (Human
UniProt Name ITA2_HUMAN (Human)

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  1. 1. Tenchini ML, Adams JC, Gilbert C, Steel J, Hudson DL, Malcovati M, et al. Evidence against a major role for integrins in calcium-dependent intercellular adhesion of epidermal keratinocytes. Cell Adhes Commun. 1993;1:55-66. (Immunogen, IP)
  2. 2. Berdichevsky F, Alford D, D-Souza B, Taylor-Papadimitriou J. Branching morphogenesis of human mammary epithelial cells in collagen gels. J Cell Sci. 1994;107:3557-68. (IP, IHC-FS)
  3. 3. Rikimaru K, Molès J, Watt FM. Correlation between hyperproliferation and suprabasal integrin expression in human epidermis reconstituted in culture. Exp Dermatol. 1997;6:214-21. (IHC-FS)
  4. 4. Malara A, Gruppi C, Rebuzzini P, Visai L, Perotti C, Moratti R, et al. Megakaryocyte-matrix interaction within bone marrow: new roles for fibronectin and factor XIII-A. Blood. 2011;117:2476-83. (ICC)
  5. 5. Alford D, Baeckström D, Geyp M, Pitha P, Taylor-Papadimitriou J. Integrin-matrix interactions affect the form of the structures developing from human mammary epithelial cells in collagen or fibrin gels. J Cell Sci. 1998;111:521-32. (Block)
  6. 6. Hangan D, Uniyal S, Morris VL, MacDonald IC, von Ballestrem C, Chau T, et al. Integrin VLA-2 (α2β1) function in postextravasation movement of human rhabdomyosarcoma RD cells in the liver. Cancer Res. 1996;56:3142-9. (IP, FC)
  7. 7. King SL, Kamata T, Cunningham JA, Emsley J, Liddington RC, Takada Y, et al. Echovirus 1 interaction with the human very late antigen-2 (integrin α2β1) I domain. Identification of two independent virus contact sites distinct from the metal ion-dependent adhesion site. J Biol Chem. 1997;272:28518-22. (FC)
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