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Mouse Anti-Human GSK-3β-SEPH (5D6)
Cat. No.:
10915-25
Agarose Anti-GSK-3β antibody for use in immunoprecipitation assays.
$468.00
| Clone | 5D6 |
|---|---|
| Isotype | Mouse (BALB/c) IgG2bκ |
| Isotype Control | 0104-25 |
| Specificity | Human GSK-3β |
| Alternative Names | Glycogen synthase kinase-3 beta |
| Description | Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3α and GSK-3β. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics, and cell motility. |
| Immunogen | Recombinant N-terminal GSK-3β |
| Conjugate | SEPH (Agarose) |
| Buffer Formulation | Borate buffered saline, pH 8.2 |
| Clonality | Monoclonal |
| Concentration | Lot specific |
| Volume | 2.0 mL |
| Recommended Storage | 2-8°C |
| Trademark Information | Sepharose® is a registered trademark of Cytiva Bioprocess R&D AB |
| Applications | Western Blot – Quality tested Immunoprecipitation – Quality tested 1,2 ELISA 3 |
| RRID Number | AB_2794547 |
| Gene ID | 2932 (Human) |
| Gene ID Symbol | GSK3B (Human) |
| UniProt ID | P49841 (Human) |
| UniProt Name | GSK3B_HUMAN (Human) |
Documentation
Certificate of Analysis Lookup
Enter the Catalog Number and Lot Number for the Certificate of Analysis you wish to view
- 1. Meares GP, Zmijewska AA, Jope RS. HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activation. Cell Signal. 2008;20:347-58. (IP)
- 2. Sun M, Song L, Li Y, Zhou T, Jope RS. Identification of an antiapoptotic protein complex at death receptors. Cell Death Differ. 2008;15:1887-1900. (IP)
- 3. SouthernBiotech unpublished data (ELISA)
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