Mouse Anti-Human IL-21-BIOT (SB134f)
Biotin Anti-Human IL-21 antibody for use in ELISA assays.
|Isotype||Mouse (BALB/c) IgG2aκ|
|Isotype Control||Mouse IgG2a-BIOT (HOPC-1)|
|Alternative Names||Interleukin-21, Za11|
|Description||Interleukin-21 (IL-21) is a four helical bundle type I cytokine. The mature form of human IL-21 is a 131 amino acid protein. IL-21 is expressed primarily by NKT and CD4+ T cells, particularly the inflammatory Th17 subset, and has pleiotropic effects on both innate and adaptive immune responses. The effects of IL-21 include promotion of antibody production, NK cell differentiation, proliferation and differentiation of cells of monocyte and granulocyte lineages, costimulation of T cells, and augmentation of antitumor activity of CD8+ T cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.|
|Immunogen||E. coli-expressed human IL-21|
|Buffer Formulation||Phosphate buffered saline containing < 0.1% sodium azide|
ELISA – Quality tested|
Note – May be paired with the purified clone SB134b (SB Cat. No. 15900-01) in a sandwich ELISA
|Gene ID Symbol||
|Gene ID Aliases||CVID11; IL-21; Za11|
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