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Mouse Anti-Porcine CD8α-PE (76-2-11)

Cat. No.:
4520-09
PE Anti-Porcine CD8α for use in flow cytometry assays.
$237.00
Size Price (USD) Quantity
0.1 mg $237.00
More Information
Clone 76-2-11
Isotype Mouse (BALB/c) IgG2aκ
Isotype Control Mouse IgG2a-PE (HOPC-1)
Specificity Porcine CD8α
Description Porcine CD8, a type I transmembrane glycoprotein, is expressed as either a CD8αα homodimer or a CD8αβ heterodimer. It is found on most thymocytes and on the suppressor/cytotoxic subpopulation of peripheral T cells. CD8 functions primarily as a co-receptor with MHC Class I-restricted T cell receptors in antigen recognition. The monoclonal antibody 76-2-11 reacts with the CD8 α-chain.
Immunogen Fresh dd miniature swine thymocytes
Conjugate PE (R-phycoerythrin)
Buffer Formulation Phosphate buffered saline containing < 0.1% sodium azide and a stabilizer
Clonality Monoclonal
Concentration 0.1 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C; Avoid exposure to light; Do not freeze
Applications Flow Cytometry – Quality tested 1,11-15,17-28
Immunohistochemistry-Frozen Sections – Reported in literature 2-6,16
Immunohistochemistry-Paraffin Sections – Reported in literature 7
Immunoprecipitation – Reported in literature 1
Blocking – Reported in literature 8,9
Depletion – Reported in literature 10
Complement Mediated Cell Depletion – Reported in literature 1

RRID Number AB_2796033
Gene ID 396627 (Porcine)
Gene ID Symbol CD8A (Porcine)

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  3. 3. Yamada K, Shimizu A, Ierino FL, Utsugi R, Barth RN, Esnaola N, et al. Thymic transplantation in miniature swine. I. Development and function of the "thymokidney". Transplantation. 1999;68:1684-92. (IHC-FS)
  4. 4. Shimizu A, Yamada K, Meehan SM, Sachs DH, Colvin RB. Acceptance reaction: intragraft events associated with tolerance to renal allografts in miniature swine. J Am Soc Nephrol. 2000;11:2371-80. (IHC-FS)
  5. 5. Shimizu A, Yamada K, Sachs DH, Colvin RB. Mechanisms of chronic renal allograft rejection. II. Progressive allograft glomerulopathy in miniature swine. Lab Invest. 2002;82:673-85. (IHC-FS)
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  7. 7. Jung K, Alekseev KP, Zhang X, Cheon D, Vlasova AN, Saif LJ. Altered pathogenesis of porcine respiratory coronavirus in pigs due to immunosuppressive effects of dexamethasone: implications for corticosteroid use in treatment of severe acute respiratory syndrome coronavirus. J Virol. 2007;81:13681-93. (IHC-PS)
  8. 8. Pescovitz MD, Lunney JK, Sachs DH. Murine anti-swine T4 and T8 monoclonal antibodies: distribution and effects on proliferative and cytotoxic T cells. J Immunol. 1985;134:37-44. (Block)
  9. 9. Saíz JC, Rodríguez A, González M, Alonso F, Sobrino F. Heterotypic lymphoproliferative response in pigs vaccinated with foot-and-mouth disease virus. Involvement of isolated capsid proteins. J Gen Virol. 1992;73:2601-7. (Block)
  10. 10. Suzuki T, Sundt TM 3rd, Mixon A, Sachs DH. In vivo treatment with antiporcine T cell antibodies. Transplantation. 1990;50:76-81. (Depletion)
  11. 11. Davis ME, Maxwell CV, Erf GF, Brown DC, Wistuba TJ. Dietary supplementation with phosphorylated mannans improves growth response and modulates immune function of weanling pigs. J Anim Sci. 2004;82:1882-91. (FC)
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  14. 14. Toka FN, Nfon CK, Dawson H, Estes DM, Golde WT. Activation of porcine natural killer cells and lysis of foot-and-mouth disease virus infected cells. J Interferon Cytokine Res. 2009;29:179-92. (FC)
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  24. 24. Thorum SC, Hester SN, Comstock SS, Monaco MH, Pence BD, Woods JA, et al. Dietary (1,3/1,6)-β-D-glucan decreases transforming growth factor β expression in the lung of the neonatal piglet. Nutr Res. 2013;33:322-31 (FC)
  25. 25. Liu Y, Che TM, Song M, Lee JJ, Almeida JA, Bravo D, et al. Dietary plant extracts improve immune responses and growth efficiency of pigs experimentally infected with porcine reproductive and respiratory syndrome virus. J Anim Sci. 2013;91:5668-79. (FC)
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  28. 28. Zhu Y, Li X, Zhang W, Zhou D, Liu H, Wang J. Dose-dependent effects of Lactobacillus rhamnosus on serum interleukin-17 production and intestinal T-cell responses in pigs challenged with Escherichia coli. Appl Environ Microbiol. 2014;80:1787-98. (FC)
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