Mouse Anti-Human IL-31-BIOT (SB118b)
Biotin Anti-Human IL-31 antibody for use in ELISA assays.
|Isotype||Mouse (BALB/c) IgG2bκ|
|Isotype Control||Mouse IgG2b-BIOT (A-1)|
|Description||Interleukin-31 (IL-31) is a 24 kDa α-helical protein and a member of the IL-6 family of cytokines that is preferentially expressed by CD4+ T cells. This cytokine elicits its response by binding to a heterodimeric complex consisting of a gp130-like receptor chain and the oncostatin M receptor subunit. On target cells which include a broad range of immune and non-immune cells, IL-31 binding can induce activation of the Jak/STAT, AKT, and MAPK signaling pathways. Due to the ubiquitous expression of its receptor complex, IL-31 has numerous physiological roles that include regulating hematopoiesis and immune response. Over-expression has been linked to chronic inflammatory states such as dermatitis, pruritus, airway hypersensitivity, and inflammatory bowel disease.|
|Immunogen||E. coli-expressed human IL-31|
|Buffer Formulation||Phosphate buffered saline containing < 0.1% sodium azide|
ELISA – Quality tested|
|Gene ID Symbol||
|Gene ID Aliases||IL-31|
Certificate of Analysis Lookup
Enter the Catalog Number and Lot Number for the Certificate of Analysis you wish to view
Need help with this product?
or call 800.722.2255