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Rat Anti-Mouse CD105-UNLB (MJ7/18)

Cat. No.:
1860-01
Purified Anti-Mouse CD105 antibody for use in flow cytometry, immunohistochemistry, western blot, immunoprecipitation, and separation assays.
$218.00
Size Price (USD) Quantity
0.5 mg $218.00
More Information
Clone MJ7/18
Isotype Rat IgG2aκ
Isotype Control Rat IgG2a-UNLB (KLH/G2a-1-1)
Specificity Mouse CD105
Alternative Names Endoglin
Description CD105, also known as endoglin, is a disulfide-linked type II transmembrane homodimer that is predominantly expressed on vascular endothelial cells. It is also found on pre-erythroblasts, macrophages, and lymphoid and myeloid leukemic cells. Both mouse and human CD105 exhibit >70% sequence homology in their cytoplasmic domains with type III transforming growth factor β (TGFβ) receptor. CD105 has been shown to be one of several receptors for the various isoforms of TGFβ which in turn is one of a family of proteins involved in regulation of cell differentiation, migration of cells, and control of the immune response.
Immunogen Inflamed mouse skin
Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Clonality Monoclonal
Concentration 0.5 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C
Applications Flow Cytometry – Quality tested 2,7-9
Immunohistochemistry-Frozen Sections – Reported in literature 6
Immunoprecipitation – Reported in literature 2
Western Blot – Reported in literature 1,2,4,5
Separation – Reported in literature 3

RRID Number AB_2795411
Gene ID 13805 (Mouse)
Gene ID Symbol Eng (Mouse)
Gene ID Aliases Endo; CD105; AI528660; AI662476; S-endoglin
UniProt ID Q63961 (Mouse)
UniProt Name EGLN_MOUSE (Mouse)

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  1. 1. Ge AZ, Butcher EC. Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF-β ligand. Gene. 1994;138:201-6. (Immunogen, WB, FC)
  2. 2. Raab U, Velasco B, Lastres P, Letamendía A, Calés C, Langa C, et al. Expression of normal and truncated forms of human endoglin. Biochem J. 1999;339:579-88. (FC, WB, IP)
  3. 3. Finkensieper A, Kieser S, Bekhite MM, Richter M, Mueller JP, Graebner R, et al. The 5-lipoxygenase pathway regulates vasculogenesis in differentiating mouse embryonic stem cells. Cardiovasc Res. 2010;86:37-44. (Sep)
  4. 4. Belik J, Jerkic M, McIntyre BA, Pan J, Leen J, Yu LX, et al. Age-dependent endothelial nitric oxide synthase uncoupling in pulmonary arteries of endoglin heterozygous mice. Am J Physiol Lung Cell Mol Physiol. 2009;297:L1170-8. (WB)
  5. 5. Jerkic M, Peter M, Ardelean D, Fine M, Konerding MA, Letarte M. Dextran sulfate sodium leads to chronic colitis and pathological angiogenesis in endoglin heterozygous mice. Inflamm Bowel Dis. 2010;16:1859-70. (WB)
  6. 6. Wickersheim A, Kerber M, de Miguel LS, Plate KH, Machein MR. Endothelial progenitor cells do not contribute to tumor endothelium in primary and metastatic tumors. Int J Cancer. 2009;125:1771-7. (IHC-FS)
  7. 7. Ren Y, Finckenstein FG, Abdueva DA, Shahbazian V, Chung B, Weinberg KI, et al. Mouse mesenchymal stem cells expressing PAX-FKHR form alveolar rhabdomyosarcomas by cooperating with secondary mutations. Cancer Res. 2008;68:6587-97. (FC)
  8. 8. Adhikari AS, Agarwal N, Wood BM, Porretta C, Ruiz B, Pochampally RR, et al. CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance. Cancer Res. 2010;70:4602-12. (FC)
  9. 9. Moorthy RK, Sam GA, Kumar SV, Chacko G, Mathews V, Chacko AG, et al. Intralesional mesenchymal stromal cell transplant in a rodent model of cortical cryoinjury. Neurol India. 2011;59:573-8. (FC)
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