Ensuring timely antibody supply during the COVID-19 pandemic - contact us for solutions

Rat Anti-Mouse CD2-BIOT (12-15)

Cat. No.:
1525-08
Biotin Anti-Mouse CD2 antibody for use in flow cytometry, immunoprecipitation, and separation assays.
$222.00
Size Price (USD) Quantity
0.5 mg $222.00
More Information
Clone 12-15
Isotype Rat (Sprague Dawley) IgG1κ
Isotype Control Rat IgG1-BIOT (KLH/G1-2-2)
Specificity Mouse CD2
Alternative Names LFA-2, T11, Ly37, SRBC-R, Leu-5, LFA-3 receptor
Description CD2, also known as leukocyte function-associated antigen-2 (LFA-2), is a member of the immunoglobulin superfamily of cell adhesion molecules. It is expressed on the surface of >95% of thymocytes, and essentially all B cells, T cells and NK cells. In the mouse, CD2 is the receptor for CD48. CD2 is thought to play a major role in mediating T-cell adhesion, T-cell recognition/activation, T-cell signaling, and intrathymic differentiation.
Immunogen Crude plasma membranes of ESb cells
Conjugate BIOT (Biotin)
Buffer Formulation Phosphate buffered saline containing < 0.1% sodium azide
Clonality Monoclonal
Concentration 0.5 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C
Applications Flow Cytometry – Quality tested 1,7,9
Immunoprecipitation – Reported in literature 1,7
Separation – Reported in literature 2
Blocking – Reported in literature 3-7
Purification – Reported in literature 1,8

RRID Number AB_2794794
Gene ID 12481 (Mouse)
Gene ID Symbol Cd2 (Mouse)
Gene ID Aliases Ly37; LFA-2; Ly-37
UniProt ID P08920 (Mouse)
UniProt Name CD2_MOUSE (Mouse)

Certificate of Analysis Lookup

Enter the Catalog Number and Lot Number for the Certificate of Analysis you wish to view


Need help with this product?
or call 800.722.2255
  1. 1. Altevogt P, Heckl-Oestreicher G, Lang E, Kohl U, Kratzin H, Schirrmacher V. Murine Fcγ receptor proteins: identification of a previously unrecognized molecule with a monoclonal antibody (12-15). Eur J Immunol. 1988;18:677-83. (Immunogen, FC, Purification, IP)
  2. 2. Fushimi S, Ogino T, Hara J, Takahata T, Wakabayashi H, Watanabe H, et al. Forced expression of suppressor of cytokine signaling 3 in T cells protects the development of concanavalin A-induced hepatitis in mice. Clin Immunol. 2009;133:437-46. (Sep)
  3. 3. Bai Y, Liu J, Wang Y, Honig S, Qin L, Boros P, et al. L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific tolerance. J Immunol. 2002;168:1579-89. (Block)
  4. 4. Ochando JC, Yoop AC, Yang Y, Garin A, Li Y, Boros P, et al. Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells. J Immunol. 2005;174:6993-7005. (Block)
  5. 5. Qin L, Chavin KD, Lin J, Yagita H, Bromberg JS. Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival. J Exp Med. 1994;179:341-6. (Block)
  6. 6. Chavin KD, Qin L, Lin J, Woodward JE, Baliga P, Bromberg JS. Combination anti-CD2 and anti-CD3 monoclonal antibodies induce tolerance while altering interleukin-2, interleukin-4, tumor necrosis factor, and transforming growth factor-β production. Ann Surg. 1993;218:492-503. (Block)
  7. 7. Altevogt P, Kohl U, Von Hoegen P, Lang E, Schirrmacher V. Antibody 12-15 cross-reacts with mouse Fcγ receptors and CD2: study of thymus expression, genetic polymorphism and biosysthesis of the CD2 protein. Eur J Immunol. 1989;19:341-6. (FC, IP, Block)
  8. 8. Ruppert M, Aigner S, Hubbe M, Yagita H, Altevogt P. The L1 adhesion molecule is a cellular ligand for VLA-5. J Cell Biol. 1995;131:1881-91. (Purification)
  9. 9. Avagyan S, Glouchkova L, Choi J, Snoeck H. A quantitative trait locus on chromosome 4 affects cycling of hematopoietic stem and progenitor cells through regulation of TGF-β2 responsiveness. J Immunol. 2008;181:5904-11. (FC)
See All References