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Rat Anti-Mouse MHC Class II-LE/AF (NIMR-4)

Cat. No.:
1895-14
Low Endotoxin/Azide Free Anti-Mouse MHC Class II antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, and separation assays.
$320.00
Size Price (USD) Quantity
0.5 mg $320.00
More Information
Clone NIMR-4
Isotype Rat IgG2bκ
Isotype Control Rat IgG2b-LE/AF (KLH/G2b-1-2)
Specificity Mouse MHC Class II
Alternative Names I-A antigen
Description The monoclonal antibody NIMR-4 reacts specifically with a non-polymorphic I-A-encoded epitope on MHC Class II antigens. Class II antigens are predominantly expressed on antigen-presenting cells including B lymphocytes, macrophages, dendritic cells, and certain epithelial cells.
Conjugate LE/AF (Low Endotoxin/Azide Free)
Buffer Formulation Phosphate buffered saline, pH 7.4
Clonality Monoclonal
Concentration 0.5 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C; Handle under aseptic conditions
Applications Flow Cytometry – Quality tested 4-13
Immunohistochemistry-Frozen Sections – Reported in literature 1
Immunocytochemistry – Reported in literature 1,2
Separation – Reported in literature 3

RRID Number AB_2795448
Gene ID 14960 (Mouse)
Gene ID Symbol H2-Aa (Mouse)
Gene ID Aliases Ia1; H2Aa; Ia-1; H-2Aa; Aalpha; IAalpha; I-Aalpha
UniProt ID P01910 (Mouse)
P04227 (Mouse)
P04228 (Mouse)
P14434 (Mouse)
P14435 (Mouse)
P14436 (Mouse)
P14437 (Mouse)
P14438 (Mouse)
P23150 (Mouse)
UniProt Name HA2K_MOUSE (Mouse)
HA2Q_MOUSE (Mouse)
HA2D_MOUSE (Mouse)
HA2B_MOUSE (Mouse)
HA2F_MOUSE (Mouse)
HA2R_MOUSE (Mouse)
HA2S_MOUSE (Mouse)
HA2U_MOUSE (Mouse)
HA2J_MOUSE (Mouse)

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  1. 1. Andrew EM, Parkhouse RM. Immune induction of Ia antigens in activated T cells and in kidney epithelial cells in mice. Immunology. 1986;58:603-6. (IHC-FS, ICC)
  2. 2. Zaliauskiene L, Kang S, Sparks K, Zinn KR, Schwiebert LM, Weaver CT, et al. Enhancement of MHC class II-restricted responses by receptor-mediated uptake of peptide antigens. J Immunol. 2002;169:2337-45. (ICC)
  3. 3. Lindsey JW. Dexamethasone-induced Ras-related protein 1 is a potential regulatory protein in B lymphocytes. Int Immunol. 2007;19:583-90. (Sep)
  4. 4. Caspar-Bauguil S, Cousin B, Galinier A, Segafredo C, Nibbelink M, André M, et al. Adipose tissues as an ancestral immune organ: site-specific change in obesity. FEBS. 2005;579:3487-92. (FC)
  5. 5. Bauer C, Bauernfeind F, Sterzik A, Orban M, Schnurr M, Lehr HA, et al. Dendritic cell-based vaccination combined with gemcitabine increases survival in a murine pancreatic carcinoma model. Gut. 2007;56:1275-82. (FC)
  6. 6. Krishnamoorthy N, Oriss TB, Paglia M, Fei M, Yarlagadda M, Vanhaesebroeck B, et al. Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma. Nat Med. 2008;14:565-73. (FC)
  7. 7. Gu T, Zhu Y, Chen C, Li M, Chen Y, Yu G, et al. Fine-tuned expression of programmed death 1 ligands in mature dendritic cells stimulated by CD40 ligand is critical for the induction of an efficient tumor specific immune response. Cell Mol Immunol. 2008;5:33-9. (FC)
  8. 8. Brix S, Lund P, Kjaer TM, Straarup EM, Hellgren LI, Frøkiær H. CD4+ T-cell activation is differentially modulated by bacteria-primed dendritic cells, but is generally down-regulated by n-3 polyunsaturated fatty acids. Immunology. 2010;129:338-50. (FC)
  9. 9. Jacobsen JT, Lunde E, Sundvold-Gjerstad V, Munthe LA, Bogen B. The cellular mechanism by which complementary Id+ and anti-Id antibodies communicate: T cells integrated into idiotypic regulation. Immunol Cell Biol. 2010;88:515-22. (FC)
  10. 10. Arora M, Poe SL, Oriss TB, Krishnamoorthy N, Yarlagadda M, Wenzel SE, et al. TLR4/MyD88-induced CD11b+Gr-1intF4/80+ non-migratory myeloid cells suppress Th2 effector function in the lung. Mucosal Immunol. 2010;3:578-93. (FC)
  11. 11. Duewell P, Kisser U, Heckelsmiller K, Hoves S, Stoitzner P, Koernig S, et al. ISCOMATRIX adjuvant combines immune activation with antigen delivery to dendritic cells in vivo leading to effective cross-priming of CD8+ T cells. J Immunol. 2011;187:55-63. (FC)
  12. 12. Szyszko EA, Skarstein K, Jonsson R, Brokstad KA. Distinct phenotypes of plasma cells in spleen and bone marrow of autoimmune NOD.B10.H2b mice. Autoimmunity. 2011;44:415-26. (FC)
  13. 13. Khare A, Krishnamoorthy N, Oriss TB, Fei M, Ray P, Ray A. Cutting edge: inhaled antigen upregulates retinaldehyde dehydrogenase in lung CD103+ but not plasmacytoid dendritic cells to induce Foxp3 de novo in CD4+ T cells and promote airway tolerance. J Immunol. 2013;191:25-29. (FC)
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