Mouse Anti-Bcl-xL-UNLB

Cat. No.
10030-01  
Size
0.1 mg   		Price (USD)
$325.00 
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Clone 7B2.5
Isotype Mouse (BALB/c) IgG3κ
Isotype Control Mouse IgG3-UNLB
Immunogen Recombinant human Bcl-xS
Specificity Human/Mouse/Rat/Rhesus Bcl-xL
Alternalte Name(s) Apoptosis regulator Bcl-X, Bcl-2-like 1 protein, BCL2L1
Description Bcl-xL is a 29 kDa member of the Bcl-2 family of proteins involved in regulation of programmed cell death, or apoptosis. It is found in both soluble and membrane fractions of cellular lysates. Like Bcl-2, Bcl-xL has been demonstrated to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2. While formation of heterodimers with the apoptosis-enhancing protein, Bax does not block the apoptosis-suppressing property of Bcl-xL, heterodimerization with Bad effectively inhibits the protective function of Bcl-xL.
Format/Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Concentration 0.1 mg/mL
Volume 1.0 mL
Storage & Handling 2-8°C
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
Flow Cytometry – Quality tested 2-25
Immunohistochemistry-Paraffin Sections – Reported in literature 26
Immunocytochemistry – Reported in literature 27
Western Blot – Reported in literature 1,28-30
Immunoprecipitation – Reported in literature 30,31
ELISA – Reported in literature 1
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2794101
Gene ID
598 (Human)
12048 (Mouse)
24888 (Rat)
713035 (Rhesus)
Gene Symbol
BCL2L1 (Human)
Bcl2l1 (Mouse)
Bcl2l1 (Rat)
BCL2L1 (Rhesus)
Gene Aliases BCL-XL/S; BCL2L; BCLX; Bcl-X; PPP1R52; Bcl(X)L; Bcl-XL; Bcl2l; BclX; bcl-x; bcl2-L-1; Bcl-xl; Bclx; bcl-X; EGK_02534
Uniprot ID
Q07817 (Human)
Q64373 (Mouse)
P53563 (Rat)
Uniprot Name
B2CL1_HUMAN 
B2CL1_MOUSE
B2CL1_RAT
  • Mouse Anti-Bcl-xL-FITC
    Human T cell leukemia cell line Jurkat was intracellularly stained with Mouse Anti-Human Bcl-xL-FITC (SB Cat. No. 10030-02).

Human T cell leukemia cell line Jurkat was intracellularly stained with Mouse Anti-Human Bcl-xL-FITC (SB Cat. No. 10030-02).
 
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References
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15. Hossain MZ, Yu Q, Xu M, Sen JM. ICAT expression disrupts β-catenin-TCF interactions and impairs survival of thymocytes and activated mature T cells. Int Immunol. 2008;20:925-35. (FC)
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19. Chang C, Lai Y, Hou M, Huang P, Liao N. IL-15Rα of radiation-resistant cells is necessary and sufficient for thymic invariant NKT cell survival and functional maturation. J Immunol. 2011;187:1235-42. (FC)
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24. Zhang T, Wu M, Sentman CL. An NKp30-based chimeric antigen receptor promotes T cell effector functions and antitumor efficacy in vivo. J Immuno. 2012;189:2290-9. (FC)
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31. Passer BJ, Pellegrini L, Vito P, Ganjei JK, D'Adamio L. Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-XL. A potential role in modulating the threshold of cell death. J Biol Chem. 1999;274:24007-13. (IP)