| Immunogen |
Recombinant N-terminal GSK-3α
|
| Alternalte Name(s) |
Glycogen synthase kinase-3 alpha
|
| Description |
Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3α and GSK-3β. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics, and cell motility.
|
| Buffer Formulation |
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
|
| Storage & Handling |
Store at 2-8°C
Please refer to product specific SDS
|
| Applications |
Applications for relevant formats of this clone include - Western Blot – Quality tested 1
|
| Recommended Dilutions |
Please refer to product specific Technical Bulletin
|