Mouse Anti-GSK-3α-UNLB

Cat. No.
10900-01  
Size
0.1 mg   		Price (USD)
$315.00 
Save in My Products of Interest
Technical Bulletin Certificate of
Analysis Safety Data Sheet Bulk/Custom
Quotation Request Email Technical
Service
Clone SBGSK3α1
Isotype Mouse (BALB/c) IgG2aκ
Isotype Control Mouse IgG2a-UNLB
Immunogen Recombinant N-terminal GSK-3α
Specificity Human/Mouse GSK-3α
Alternalte Name(s) Glycogen synthase kinase-3 alpha
Description Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3α and GSK-3β. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics, and cell motility.
Format/Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Concentration 0.5 mg/mL
Volume 0.2 mL
Storage & Handling 2-8°C
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
Western Blot – Quality tested 1
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2794515
Gene ID
2931 (Human)
606496 (Mouse)
Gene Symbol
GSK3A (Human)
Gsk3a (Mouse)
Gene Aliases 2700086H06Rik
Uniprot ID
P49840 (Human)
Q2NL51 (Mouse)
Uniprot Name
GSK3A_HUMAN 
GSK3A_MOUSE
  • Mouse Anti-GSK-3a-UNLB
    Total cell lysates from Jurkat cells were resolved by electrophoresis, transferred to PVDF membrane, and probed with Mouse Anti-GSK-3α-UNLB (SB Cat. No. 10900-01). Proteins were visualized using Goat Anti-Mouse IgG, Human ads-HRP (SB Cat. No. 1030-05) secondary antibody and chemiluminescent detection.

Total cell lysates from Jurkat cells were resolved by electrophoresis, transferred to PVDF membrane, and probed with Mouse Anti-GSK-3α-UNLB (SB Cat. No. 10900-01). Proteins were visualized using Goat Anti-Mouse IgG, Human ads-HRP (SB Cat. No. 1030-05) secondary antibody and chemiluminescent detection.
 
Related Products (12)
References
1. Sun M, Song L, Li Y, Zhou T, Jope RS. Identification of an antiapoptotic protein complex at death receptors. Cell Death Differ. 2008;15:1887-1900. (WB)