Unlabeled Anti-GSK-3a, SBGSK3a1

Cat. No.
10900-01

Size
0.1 mg

Price (USD)
$315.00

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Clone	SBGSK3a1
Isotype	Mouse (BALB/c) IgG_2aκ
Isotype Control	Mouse IgG_2a-UNLB
Immunogen	Recombinant N-terminal GSK-3α
Specificity	Human/Mouse GSK-3α
Alternalte Name(s)	Glycogen synthase kinase-3 alpha
Description	Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3α and GSK-3β. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics, and cell motility.
Format/Conjugate	UNLB (Unconjugated)
Buffer Formulation	Borate buffered saline, pH 8.2
Concentration	0.5 mg/mL
Volume	0.2 mL
Storage & Handling	2-8°C Please refer to product specific SDS
Applications	Applications for relevant formats of this clone include - Western Blot – Quality tested ¹
Recommended Dilutions	Please refer to product specific Technical Bulletin
RRID	AB_2794515

Total cell lysates from Jurkat cells were resolved by electrophoresis, transferred to PVDF membrane, and probed with Mouse Anti-GSK-3α-UNLB (SB Cat. No. 10900-01). Proteins were visualized using Goat Anti-Mouse IgG, Human ads-HRP (SB Cat. No. 1030-05) secondary antibody and chemiluminescent detection.

Total cell lysates from Jurkat cells were resolved by electrophoresis, transferred to PVDF membrane, and probed with Mouse Anti-GSK-3α-UNLB (SB Cat. No. 10900-01). Proteins were visualized using Goat Anti-Mouse IgG, Human ads-HRP (SB Cat. No. 1030-05) secondary antibody and chemiluminescent detection.