HRP Anti-GSK-3a, SBGSK3a2 | SouthernBiotech

Cat. No.
10905-05

Size
1.0 mL

Price (USD)
$360.00

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Clone	SBGSK3a2
Isotype	Mouse (BALB/c) IgG_2aκ
Isotype Control	Mouse IgG_2a-HRP
Immunogen	Recombinant N-terminal GSK-3α
Specificity	Human/Mouse GSK-3α
Alternalte Name(s)	Glycogen synthase kinase-3 alpha
Description	Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3α and GSK-3β. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics, and cell motility.
Format/Conjugate	HRP (Horseradish Peroxidase)
Buffer Formulation	50% Glycerol/50% Phosphate buffered saline, pH 7.4
Volume	1.0 mL
Storage & Handling	2-8°C Please refer to product specific SDS
Applications	Applications for relevant formats of this clone include - Western Blot – Quality tested ¹
Recommended Dilutions	Please refer to product specific Technical Bulletin
RRID	AB_2794535

Gene ID	2931 (Human) 606496 (Mouse)
Gene Symbol	GSK3A (Human) Gsk3a (Mouse)
Gene Aliases	2700086H06Rik
Uniprot ID	P49840 (Human) Q2NL51 (Mouse)
Uniprot Name	GSK3A_HUMAN GSK3A_MOUSE

GSK3α was immunoprecipitated from total cell lysates from Jurkat cells with Mouse Anti-GSK-3α-UNLB (SB Cat. No. 10910-01). Total cell lysates from Jurkat cells (Lane 1) and immunoprecipitate (Lane 2) were resolved by electrophoresis, transferred to PVDF membrane, and probed with Mouse Anti-GSK-3α-HRP (SB Cat. No. 10905-05). Proteins were visualized using chemiluminescent detection.

GSK3α was immunoprecipitated from total cell lysates from Jurkat cells with Mouse Anti-GSK-3α-UNLB (SB Cat. No. 10910-01). Total cell lysates from Jurkat cells (Lane 1) and immunoprecipitate (Lane 2) were resolved by electrophoresis, transferred to PVDF membrane, and probed with Mouse Anti-GSK-3α-HRP (SB Cat. No. 10905-05). Proteins were visualized using chemiluminescent detection.