| Immunogen |
Recombinant N-terminal GSK-3α
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| Alternalte Name(s) |
Glycogen synthase kinase-3 alpha
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| Description |
Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3α and GSK-3β. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics, and cell motility.
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| Buffer Formulation |
Supplied in a stock solution of 50% glycerol/50% PBS, pH 7.4; No preservative added
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| Storage & Handling |
Store at 2-8°C
Please refer to product specific SDS
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| Applications |
Applications for relevant formats of this clone include - Western Blot – Quality tested 1
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| Recommended Dilutions |
Please refer to product specific Technical Bulletin
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