Mouse Anti-Human GSK-3β-UNLB

Cat. No.
10920-01  
Size
0.1 mg  
Price (USD)
$300.00 
Clone 3A11
Isotype Mouse (BALB/c) IgG2aκ
Isotype Control Mouse IgG2a-UNLB
Immunogen Recombinant N-terminal GSK-3β
Specificity Human GSK-3β
Alternalte Name(s) Glycogen synthase kinase-3 beta
Description Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3α and GSK-3β. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics, and cell motility.
Format/Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Concentration 0.5 mg/mL
Volume 0.2 mL
Storage & Handling 2-8°C
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
ELISA – Quality tested
Immunoblotiing – Reported in literature 1
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2794548
Gene ID
2932 (Human)
Gene Symbol
GSK3B (Human)
Uniprot ID
P49841 (Human)
Uniprot Name
  • GSK3β was immunoprecipitated from total cell lysates from Jurkat cells with Mouse Anti-GSK-3β-SEPH (SB Cat. No. 10915-25). Immunoprecipitate was resolved by electrophoresis, transferred to PVDF membrane, and probed with Mouse Anti-GSK-3β-HRP (SB Cat. No. 10920-05). Proteins were visualized using chemiluminescent detection.

GSK3β was immunoprecipitated from total cell lysates from Jurkat cells with Mouse Anti-GSK-3β-SEPH (SB Cat. No. 10915-25). Immunoprecipitate was resolved by electrophoresis, transferred to PVDF membrane, and probed with Mouse Anti-GSK-3β-HRP (SB Cat. No. 10920-05). Proteins were visualized using chemiluminescent detection.
 
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References
1. Sun M, Song L, Li Y, Zhou T, Jope RS. Identification of an antiapoptotic protein complex at death receptors. Cell Death Differ. 2008;15:1887-1900. (WB)