Mouse Anti-Human GSK-3β-UNLB (3A11)
Cat. No.:
10920-01
Purified Anti-GSK-3β antibody for use in ELISA and western blot assays.
$330.00
Clone | 3A11 |
---|---|
Isotype | Mouse (BALB/c) IgG2aκ |
Isotype Control | Mouse IgG2a-UNLB (HOPC-1) |
Specificity | Human GSK-3β |
Alternative Names | Glycogen synthase kinase-3 beta |
Description | Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3α and GSK-3β. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics, and cell motility. |
Immunogen | Recombinant N-terminal GSK-3β |
Conjugate | UNLB (Unconjugated) |
Buffer Formulation | Borate buffered saline, pH 8.2 |
Clonality | Monoclonal |
Concentration | 0.5 mg/mL |
Volume | 0.2 mL |
Recommended Storage | 2-8°C |
Applications |
ELISA – Quality tested Immunoblotiing – Reported in literature 1 |
RRID Number | AB_2794548 |
Gene ID |
2932 (Human) |
Gene ID Symbol |
GSK3B (Human) |
UniProt ID |
P49841 (Human) |
UniProt Name |
GSK3B_HUMAN (Human) |
Documentation
Certificate of Analysis Lookup
Enter the Catalog Number and Lot Number for the Certificate of Analysis you wish to view
- 1. Sun M, Song L, Li Y, Zhou T, Jope RS. Identification of an antiapoptotic protein complex at death receptors. Cell Death Differ. 2008;15:1887-1900. (WB)