| Alternalte Name(s) |
FAS-associated death domain protein, GIG3, MGC8528, MORT1
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| Description |
Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1β-converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation.
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| Buffer Formulation |
Supplied in a stock solution of 50% glycerol/50% PBS, pH 7.4; No preservative added
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| Storage & Handling |
Store at 2-8°C
Please refer to product specific SDS
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| Applications |
Applications for relevant formats of this clone include - ELISA – Quality tested
Western Blot – Quality tested
Immunoprecipitation – Quality tested
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| Recommended Dilutions |
Please refer to product specific Technical Bulletin
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