Mouse Anti-Human TLR2-BIOT

Cat. No.
11000-08  
Size
0.1 mg   		Price (USD)
$240.00 
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Clone 2B4A1
Isotype Mouse (BALB/c) IgG2aκ
Isotype Control Mouse IgG2a-BIOT
Immunogen Recombinant TLR2
Specificity Human/Canine TLR2
Alternalte Name(s) Toll-like receptor 2, CD282, TIL4
Description The Toll-like receptor (TLR) family is comprised of type I transmembrane proteins characterized by an extracellular leucine-rich domain and a cytoplasmic tail that contains a conserved region call the Toll/IL-1 (TIR) domain. First discovered in Drosophila, TLRs recognize specific molecular patterns that are present in microbial components and respond to these components in order eliminate or limit invading microbes. TLR2 recognizes and is activated by components from a broad variety of microorganisms including lipoproteins from Gram-negative and Gram-positive bacteria, lipoteichoic acid from Gram-positive bacteria, lipoarabinomannan from mycobacteria, and zymosan from yeast. TLR2 has been reported to functionally associate with TLR1 and TLR6 in order to recognize various lipopeptides.
Format/Conjugate BIOT (Biotin)
Buffer Formulation Phosphate buffered saline containing 0.1% sodium azide
Concentration 0.5 mg/mL
Volume 0.2 mL
Storage & Handling 2-8°C
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
Flow Cytometry – Quality tested 1-3
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2794565
Gene ID
7097 (Human)
448807 (Canine)
Gene Symbol
TLR2 (Human)
TLR2 (Canine)
Gene Aliases CD282; TIL4
Uniprot ID
O60603 (Human)
Q689D1 (Canine)
Uniprot Name
TLR2_HUMAN 
TLR2_CANLF
  • Mouse Anti-Human TLR2-APC
    Human peripheral blood monocytes were stained with Mouse Anti-Human TLR2-APC (SB Cat. No. 11000-11).

Human peripheral blood monocytes were stained with Mouse Anti-Human TLR2-APC (SB Cat. No. 11000-11).
 
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References
1. Amorim IF, Silva SM, Figueiredo MM, Moura EP, Castro RS, Lima TK, et al. Toll receptors type-2 and CR3 expression of canine monocytes and its correlation with immunohistochemistry and xenodiagnosis in visceral leishmaniasis. PLoS One. 2011;6(11):e27679. (FC, Canine Reactivity)
2. Rolf N, Kariminia A, Ivison S, Reid GS, Schultz KR. Heterodimer-specific TLR2 stimulation results in divergent functional outcomes in B-cell precursor acute lymphoblastic leukemia. Eur J Immunol. 2015;45:1980-90. (FC)
3. Lashkari B, Anumba DO. Estradiol alters the immune-responsiveness of cervical epithelial cells stimulated with ligands of Toll-like receptors 2 and 4. PLoS One. 2017;12(3):e0173646. (FC)