Mouse Anti-Human TRAIL-UNLB

Cat. No.
11040-01  
Size
0.5 mg  
Price (USD)
$250.00 
Clone SB91a
Isotype Mouse (BALB/c) IgG2bκ
Isotype Control Mouse IgG2b-UNLB
Immunogen Recombinant TRAIL
Specificity Human TRAIL
Alternalte Name(s) CD253, Apo-2 ligand, Apo-2L, TNFSF10
Description Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family of cytokines. This type II transmembrane protein is expressed by several cytotoxic immune cells, including natural killer cells and activated T cells, and is selective for tumorigenic and virally infected cells. TRAIL can bind to DR4 and DR5 receptors on target cells which facilitates recruitment of numerous signaling proteins to form a death-inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of caspase-8.

Numerous studies have identified TRAIL as a potent apoptotic factor in a variety of human cancer cell lines, but this cytokine does not appear to affect normal cell lines. Therefore, the selectivity and anti-tumorigenic properties of TRAIL make it an intriguing and potentially therapeutic agent in the treatment of cancer.
Format/Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Concentration 0.5 mg/mL
Volume 1.0 mL
Storage & Handling 2-8°C
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
ELISA – Quality tested
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2794597
Gene ID
8743 (Human)
Gene Symbol
TNFSF10 (Human)
Gene Aliases APO2L; Apo-2L; CD253; TL2; TNLG6A; TRAIL
Uniprot ID
P50591 (Human)
Uniprot Name
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