Mouse Anti-Human TRAIL-BIOT
Cat. No.
11040-08
|
Size
0.5 mg
|
Price (USD)
$290.00
|
| Clone |
SB91a
|
| Isotype |
Mouse (BALB/c) IgG2bκ
|
| Isotype Control |
Mouse IgG2b-BIOT
|
| Immunogen |
Recombinant TRAIL
|
| Specificity |
Human TRAIL
|
| Alternalte Name(s) |
CD253, Apo-2 ligand, Apo-2L, TNFSF10
|
| Description |
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family of cytokines. This type II transmembrane protein is expressed by several cytotoxic immune cells, including natural killer cells and activated T cells, and is selective for tumorigenic and virally infected cells. TRAIL can bind to DR4 and DR5 receptors on target cells which facilitates recruitment of numerous signaling proteins to form a death-inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of caspase-8.
Numerous studies have identified TRAIL as a potent apoptotic factor in a variety of human cancer cell lines, but this cytokine does not appear to affect normal cell lines. Therefore, the selectivity and anti-tumorigenic properties of TRAIL make it an intriguing and potentially therapeutic agent in the treatment of cancer.
|
| Format/Conjugate |
BIOT (Biotin)
|
| Buffer Formulation |
Phosphate buffered saline containing < 0.1% sodium azide
|
| Concentration |
0.5 mg/mL
|
| Volume |
1.0 mL
|
| Storage & Handling |
2-8°C
Please refer to product specific SDS
|
| Applications |
Applications for relevant formats of this clone include - ELISA – Quality tested
|
| Recommended Dilutions |
Please refer to product specific Technical Bulletin
|
| RRID |
AB_2794598
|
| Gene ID |
|
| Gene Symbol |
|
| Gene Aliases |
APO2L; Apo-2L; CD253; TL2; TNLG6A; TRAIL
|
| Uniprot ID |
|
| Uniprot Name |
|
|
|
|