Mouse Anti-Human TRAIL-BIOT
Cat. No.
11040-08
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Size
0.5 mg
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Price (USD)
$290.00
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| Clone |
SB91a
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| Isotype |
Mouse (BALB/c) IgG2bκ
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| Isotype Control |
Mouse IgG2b-BIOT
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| Immunogen |
Recombinant TRAIL
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| Specificity |
Human TRAIL
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| Alternalte Name(s) |
CD253, Apo-2 ligand, Apo-2L, TNFSF10
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| Description |
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family of cytokines. This type II transmembrane protein is expressed by several cytotoxic immune cells, including natural killer cells and activated T cells, and is selective for tumorigenic and virally infected cells. TRAIL can bind to DR4 and DR5 receptors on target cells which facilitates recruitment of numerous signaling proteins to form a death-inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of caspase-8.
Numerous studies have identified TRAIL as a potent apoptotic factor in a variety of human cancer cell lines, but this cytokine does not appear to affect normal cell lines. Therefore, the selectivity and anti-tumorigenic properties of TRAIL make it an intriguing and potentially therapeutic agent in the treatment of cancer.
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| Format/Conjugate |
BIOT (Biotin)
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| Buffer Formulation |
Phosphate buffered saline containing 0.1% sodium azide
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| Concentration |
0.5 mg/mL
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| Volume |
1.0 mL
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| Storage & Handling |
2-8°C
Please refer to product specific SDS
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| Applications |
Applications for relevant formats of this clone include - ELISA – Quality tested
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| Recommended Dilutions |
Please refer to product specific Technical Bulletin
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| RRID |
AB_2794598
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| Gene ID |
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| Gene Symbol |
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| Gene Aliases |
APO2L; Apo-2L; CD253; TL2; TNLG6A; TRAIL
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| Uniprot ID |
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| Uniprot Name |
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