Mouse Anti-Human TIMP-4-UNLB

Cat. No.
12035-01  
Size
0.1 mg   		Price (USD)
$205.00 
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Technical Bulletin Certificate of
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Clone SB30c
Isotype Mouse (BALB/c) IgG2aκ
Isotype Control Mouse IgG2a-UNLB
Immunogen Recombinant human TIMP-4 (a.a. 35-224)
Specificity Human/Mouse/Rat TIMP-4
Alternalte Name(s) Tissue inhibitor of metalloproteinase 4
Description Tissue inhibitors of matrix metalloproteinases (TIMPs) constitute a family of secreted multifunctional proteins which are classified based on structural similarity to each other as well as their ability to inhibit matrix metalloproteinases (MMPs). TIMPs play a critical role in ECM homeostasis but have also been shown to have erythroid-potentiating and cell growth-promoting activities. TIMP-4, unlike TIMP-1, TIMP-2 and TIMP-3, shows restricted localization to cardiac, neural, breast, and muscle tissue. Cardiospecific TIMP-4 seems to play a significant role in regulating the normal cell phenotype since reduced levels elicit cellular transformation.
Format/Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Concentration 0.5 mg/mL
Volume 0.2 mL
Storage & Handling 2-8°C
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
Western Blot – Quality tested 1-3
Immunohistochemistry-Paraffin Sections 4
Immunocytochemistry 4
ELISA 5
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2794707
Gene ID
7079 (Human)
110595 (Mouse)
680130 (Rat)
Gene Symbol
TIMP4 (Human)
Timp4 (Mouse)
Timp4 (Rat)
Gene Aliases TIMP-4; Timp-4
Uniprot ID
Q99727 (Human)
Q9JHB3 (Mouse)
P81556 (Rat)
Uniprot Name
TIMP4_HUMAN 
TIMP4_MOUSE
TIMP4_RAT
  • Mouse Anti-Human TIMP-4-UNLB
    Paraffin embedded human gastric cancer tissue was stained with Mouse Anti-Human TIMP-4-UNLB (SB. Cat. No. 12035-01; right) followed by followed by HRP conjugated Anti-Mouse Ig secondary antibody, DAB, and hematoxylin.
  • Mouse Anti-Human TIMP-4-UNLB
    Human pancreatic carcinoma cell line MIA PaCa-2 was stained with Mouse Anti-Human TIMP-4-UNLB (SB. Cat. No. 12035-01) followed by Goat Anti-Mouse Ig, Human ads-FITC (SB. Cat. No. 1010-02) and DAPI.

Paraffin embedded human gastric cancer tissue was stained with Mouse Anti-Human TIMP-4-UNLB (SB. Cat. No. 12035-01; right) followed by followed by HRP conjugated Anti-Mouse Ig secondary antibody, DAB, and hematoxylin.
 

Human pancreatic carcinoma cell line MIA PaCa-2 was stained with Mouse Anti-Human TIMP-4-UNLB (SB. Cat. No. 12035-01) followed by Goat Anti-Mouse Ig, Human ads-FITC (SB. Cat. No. 1010-02) and DAPI.
 
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References
1. Alarab M, Kufaishi H, Lye S, Drutz H, Shynlova O. Expression of extracellular matrix-remodeling proteins is altered in vaginal tissue of premenopausal women with severe pelvic organ prolapse. Reprod Sci. 2014;21:704-15. (WB)
2. Zambirinis CP, Levie E, Nguy S, Avanzi A, Barilla R, Xu Y, et al. TLR9 ligation in pancreatic stellate cells promotes tumorigenesis. J Exp Med. 2015;212:2077-94. (WB, Mouse Reactivity)
3. Ketsawatsomkron P, Keen HL, Davis DR, Lu K, Stump M, De Silva TM, et al. Protective role for tissue inhibitor of metalloproteinase-4, a novel peroxisome proliferator-activated receptor-γ target gene, in smooth muscle in deoxycorticosterone acetate-salt hypertension. Hypertension. 2016;67:214-22. (WB, Mouse & Rat Reactivity)
4. SouthernBiotech published data (IHC-PS, ICC)
5. SouthernBiotech unpublished data (ELISA)