Mouse Anti-Human Tollip-UNLB

Cat. No.
12060-01  
Size
0.1 mg  
Price (USD)
$310.00 
Clone SB40a
Isotype Mouse (BALB/c) IgG2aκ
Isotype Control Mouse IgG2a-UNLB
Immunogen Recombinant full length Tollip
Specificity Human Tollip
Alternalte Name(s) Toll interacting protein, IL-1RAcPIP
Description Tollip, also known as Toll interacting protein, is a 30 kDa ubiquitin-binding protein that is a component of the signaling pathway of IL-1 and Toll-like receptors. It performs multiple functions and is classified as an adaptor protein. Tollip interacts with IRAK-1 (IL-1 receptor-associated kinase 1) prior to IL-1β stimulation and suppresses the kinase activity of IRAK-1. Tollip also associates with Tom1 forming a complex which regulates endosomal trafficking of ubiquitinated proteins.
Format/Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Concentration 0.5 mg/mL
Volume 0.2 mL
Storage & Handling 2-8°C
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
Flow Cytometry – Quality tested 1
Western Blot 2
ELISA 2
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2794709
Gene ID
54472 (Human)
Gene Symbol
TOLLIP (Human)
Gene Aliases IL-1RAcPIP
Uniprot ID
Q9H0E2 (Human)
Uniprot Name
  • Human T cell leukemia cell line Jurkat was intracellularly stained with Mouse Anti-Human Tollip-UNLB (SB Cat. No. 12060-01) followed by Goat Anti-Mouse IgG2a, Human ads-PE (SB Cat. No. 1080-09).

Human T cell leukemia cell line Jurkat was intracellularly stained with Mouse Anti-Human Tollip-UNLB (SB Cat. No. 12060-01) followed by Goat Anti-Mouse IgG2a, Human ads-PE (SB Cat. No. 1080-09).
 
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References
1. Blok DC, Kager LM, Hoogendijk AJ, Lede IO, Rahman W, Afroz R, et al. Expression of inhibitory regulators of innate immunity in patients with active tuberculosis. BMC Infect Dis. 2015;15:98. (FC)
2. SouthernBiotech unpublished data (WB, ELISA)