Mouse Anti-Human Caspase-3-HRP

Cat. No.
17200-05  
Size
1.0 mL  
Price (USD)
$175.00 
Clone SB71b
Isotype Mouse (BALB/c) IgG2aκ
Isotype Control Mouse IgG2a-HRP
Immunogen Recombinant human caspase-3
Specificity Human caspase-3
Alternalte Name(s) SPP32, Yama, apopain
Description The caspases are a family of cysteine proteases that induce apoptosis in response to a variety of intra- and extracellular stimuli. These enzymes are synthesized as inactive precursors which become cleaved at aspartate-specific sites upon induction of apoptosis. Caspase-3 is one of the best characterized caspases in terms of specificity and function in apoptosis. It is a ubiquitously expressed protein in mammals and is highly prevalent in cells with lymphocytic origins, indicating a regulatory role in the immune system. Caspase-3 plays a critical role during embryonic development by inducing morphogenetic cell death in the mammalian brain and has also been linked to chromatin condensation, DNA fragmentation, and blebbing.

The SB71b monoclonal antibody detects endogenous levels of full length caspase-3 (35 kDa) and the large fragment of caspase-3 resulting from cleavage (17 kDa).
Format/Conjugate HRP (Horseradish Peroxidase)
Buffer Formulation 50% Glycerol/50% Phosphate buffered saline, pH 7.4
Volume 1.0 mL
Storage & Handling 2-8°C
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
Western Blot – Quality tested
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2795189
Gene ID
836 (Human)
Gene Symbol
CASP3 (Human)
Gene Aliases CPP32; CPP32B; SCA-1
Uniprot ID
P42574 (Human)
Uniprot Name
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