Hamster Anti-Mouse CD152-UNLB

Cat. No.
1791-01  
Size
0.5 mg  
Price (USD)
$192.00 
Clone 9H10
Isotype Hamster (Syrian) IgG2
Isotype Control Hamster IgG-UNLB
Immunogen Heat-killed Staphylococcus A bacteria coated with mouse CTLA-4/human IgG1 fusion protein
Specificity Mouse CD152
Alternalte Name(s) CTLA-4, cytotoxic T-lymphocyte protein 4
Description CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28. Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80 and CD86) on antigen-presenting cells. CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T cell stimulation via the T cell receptor (TCR) complex. Whereas CD28 provides a positive costimulatory signal, CD152 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signaling through the TCR through its association with tyrosine phosphatases such as SHP-2.
Format/Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Concentration 0.5 mg/mL
Volume 1.0 mL
Storage & Handling 2-8°C
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
ELISA – Quality tested 3
Flow Cytometry – Reported in literature 1
Immunoprecipitation – Reported in literature 2
Costimulation – Reported in literature 1
Blocking – Reported in literature 1,4
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2795296
Gene ID
12477 (Mouse)
Gene Symbol
Ctla4 (Mouse)
Gene Aliases Cd152; Ly-56; Ctla-4
Uniprot ID
P09793 (Mouse)
Uniprot Name
Related Products (8)
References
1. Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med. 1995;182:459-65. (Immunogen, FC, Costim, Block)
2. Zhang Y, Allison JP. Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. Proc Natl Acad Sci USA. 1997;94:9273-78. (IP)
3. Ward FJ, Dahal LN, Wijesekera SK, Abdul-Jawad SK, Kaewarpai T, Xu H, et al. The soluble isoform of CTLA-4 as a regulator of T-cell responses. Eur J Immunol. 2013;43:1274-85. (ELISA)
4. Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science. 1996;271:1734-36. (Block)