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Hamster Anti-Mouse CD152-UNLB (9H10)
Cat. No.:
1791-01
Purified Anti-Mouse CD152 antibody for use in flow cytometry, ELISA, blocking, and costimulation assays.
$223.00
| Clone | 9H10 |
|---|---|
| Isotype | Hamster (Syrian) IgG2 |
| Isotype Control | Hamster IgG-UNLB |
| Specificity | Mouse CD152 |
| Alternative Names | CTLA-4, cytotoxic T-lymphocyte protein 4 |
| Description | CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28. Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80 and CD86) on antigen-presenting cells. CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T cell stimulation via the T cell receptor (TCR) complex. Whereas CD28 provides a positive costimulatory signal, CD152 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signaling through the TCR through its association with tyrosine phosphatases such as SHP-2. |
| Immunogen | Heat-killed Staphylococcus A bacteria coated with mouse CTLA-4/human IgG1 fusion protein |
| Conjugate | UNLB (Unconjugated) |
| Buffer Formulation | Borate buffered saline, pH 8.2 |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C |
| Applications | ELISA – Quality tested 3 Flow Cytometry – Reported in literature 1 Immunoprecipitation – Reported in literature 2 Costimulation – Reported in literature 1 Blocking – Reported in literature 1,4 |
| RRID Number | AB_2795296 |
| Gene ID | 12477 (Mouse) |
| Gene ID Symbol | Ctla4 (Mouse) |
| Gene ID Aliases | Cd152; Ly-56; Ctla-4 |
| UniProt ID | P09793 (Mouse |
| UniProt Name | CTLA4_MOUSE (Mouse) |
Documentation
Certificate of Analysis Lookup
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- 1. Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med. 1995;182:459-65. (Immunogen, FC, Costim, Block)
- 2. Zhang Y, Allison JP. Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. Proc Natl Acad Sci USA. 1997;94:9273-78. (IP)
- 3. Ward FJ, Dahal LN, Wijesekera SK, Abdul-Jawad SK, Kaewarpai T, Xu H, et al. The soluble isoform of CTLA-4 as a regulator of T-cell responses. Eur J Immunol. 2013;43:1274-85. (ELISA)
- 4. Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science. 1996;271:1734-36. (Block)
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