Hamster Anti-Mouse CD152-UNLB
Cat. No.
1791-01
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Size
0.5 mg
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Price (USD)
$192.00
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Clone |
9H10
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Isotype |
Hamster (Syrian) IgG2
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Isotype Control |
Hamster IgG-UNLB
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Immunogen |
Heat-killed Staphylococcus A bacteria coated with mouse CTLA-4/human IgG1 fusion protein
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Specificity |
Mouse CD152
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Alternalte Name(s) |
CTLA-4, cytotoxic T-lymphocyte protein 4
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Description |
CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28. Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80 and CD86) on antigen-presenting cells. CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T cell stimulation via the T cell receptor (TCR) complex. Whereas CD28 provides a positive costimulatory signal, CD152 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signaling through the TCR through its association with tyrosine phosphatases such as SHP-2.
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Format/Conjugate |
UNLB (Unconjugated)
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Buffer Formulation |
Borate buffered saline, pH 8.2
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Concentration |
0.5 mg/mL
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Volume |
1.0 mL
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Storage & Handling |
2-8°C
Please refer to product specific SDS
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Applications |
Applications for relevant formats of this clone include - ELISA – Quality tested 3 Flow Cytometry – Reported in literature 1 Immunoprecipitation – Reported in literature 2 Costimulation – Reported in literature 1 Blocking – Reported in literature 1,4
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Recommended Dilutions |
Please refer to product specific Technical Bulletin
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RRID |
AB_2795296
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Gene ID |
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Gene Symbol |
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Gene Aliases |
Cd152; Ly-56; Ctla-4
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Uniprot ID |
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Uniprot Name |
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References
1. | Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med. 1995;182:459-65. (Immunogen, FC, Costim, Block) | 2. | Zhang Y, Allison JP. Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. Proc Natl Acad Sci USA. 1997;94:9273-78. (IP) | 3. | Ward FJ, Dahal LN, Wijesekera SK, Abdul-Jawad SK, Kaewarpai T, Xu H, et al. The soluble isoform of CTLA-4 as a regulator of T-cell responses. Eur J Immunol. 2013;43:1274-85. (ELISA) | 4. | Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science. 1996;271:1734-36. (Block) |
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