Hamster Anti-Mouse Ly-49C/F/H/I-UNLB

Cat. No.
1801-01  
Size
0.5 mg   		Price (USD)
$198.00 
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Clone 14B11
Isotype Hamster (Syrian) IgG1
Isotype Control Hamster IgG-UNLB
Immunogen IL-2 activated natural killed (A-LAK) cells from C57BL/6 mice
Specificity Mouse Ly-49C/F/H/I
Alternalte Name(s) Ly-49
Description The monoclonal antibody 14B11 reacts with murine Ly49C, Ly49F, Ly49H, and Ly49I, members of the lectin-like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells while allowing them to attack infected or transformed cells in which class I molecules have been downregulated. These inhibitory receptors are also expressed on a subpopulation of mouse CD8+ T cells. The 14B11 antibody stains ~90% of NK1.1+CD3- splenocytes and ~6% of CD8+ spleen cells from C57BL/6 mice. The antibody also stains 30-80% of NK1.1+CD3- splenocytes in other mouse strains tested (BALB/c, C3H, 129, SJL, AKR/J).
Format/Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Concentration 0.5 mg/mL
Volume 1.0 mL
Storage & Handling 2-8°C
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
Flow Cytometry – Quality tested 1,2
Cytoxicity – Reported in literature 1
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2795327
Gene ID
16634 (Mouse)
16637 (Mouse)
16639 (Mouse)
16640 (Mouse)
Gene Symbol
Klra3 (Mouse)
Klra6 (Mouse)
Klra8 (Mouse)
Klra9 (Mouse)
Gene Aliases 5E6; Ly49c; NK-2.1; Nk-2; Nk2; Nk2.1; Ly49f; ly-49f; Cmv-1; Cmv1; Ly49h; Ly49u<129>; LY49I1; Ly49I
Uniprot ID
Q64329 (Mouse)
Q60653 (Mouse)
Q60682 (Mouse)
Q2TJJ8 (Mouse)
Uniprot Name
KLRA3_MOUSE 
KLRA6_MOUSE
KLRA8_MOUSE
Q2TJJ8_MOUSE
  • Hamster Anti-Mouse Ly-49C/F/H/I-PE
    C57BL/6 mouse splenocytes were stained with Hamster Anti-Mouse Ly-49C/F/H/I-PE (SB Cat. No. 1801-09) and Mouse Anti-Mouse NK1.1-FITC (SB Cat. No. 1805-02).

C57BL/6 mouse splenocytes were stained with Hamster Anti-Mouse Ly-49C/F/H/I-PE (SB Cat. No. 1801-09) and Mouse Anti-Mouse NK1.1-FITC (SB Cat. No. 1805-02).
 
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References
1. Corral L, Takizawa H, Hanke T, Jamieson AM, Raulet DH. A new monoclonal antibody reactive with several Ly49 NK cell receptors mediates redirected lysis of target cells. Hybridoma. 1999;18:359-66. (Immunogen, Cyto, FC)
2. Chung JW, Kim MS, Piao Z, Jeong M, Yoon SR, Shin N, et al. Osteopontin promotes the development of natural killer cells from hematopoietic stem cells. Stem Cells. 2008;26:2114-23. (FC)