Rat Anti-Mouse CD5-PE

Cat. No.
1546-09L  
Size
0.2 mg  
Price (USD)
$260.00 
Clone 4H8E5
Isotype Rat IgG2aκ
Isotype Control Rat IgG2a-PE
Specificity Mouse CD5
Alternalte Name(s) Lyt-1, Ly-1, Lymphocyte antigen 1, Ly-12, Ly-A, T1, Tp67
Description CD5, also known as Lyt-1, is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B-cell antigen CD72. The frequency of CD5+ B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B-1 cells. Binding of CD5 on the T cell surface can augment alloantigen- or mitogen-induced lymphocyte proliferation and induces increased cytosolic free calcium, IL-2 secretion, and IL-2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T-cell and B-cell receptors.
Format/Conjugate PE (R-phycoerythrin)
Buffer Formulation Phosphate buffered saline containing 0.1% sodium azide and a stabilizer
Concentration 0.1 mg/mL
Volume 2.0 mL
Storage & Handling 2-8°C; Avoid exposure to light; Do not freeze
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
Flow Cytometry – Quality tested 1
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2794860
Gene ID
12507 (Mouse)
Gene Symbol
Cd5 (Mouse)
Gene Aliases Ly-1; Ly-12; Ly-A; Lyt-1
Uniprot ID
P13379 (Mouse)
Uniprot Name
  • C57BL/6 mouse splenocytes were stained with Rat Anti-Mouse CD5-PE (SB Cat. No. 1546-09L) and Rat Anti-Mouse CD3ε-FITC (SB Cat. No. 1535-02).

C57BL/6 mouse splenocytes were stained with Rat Anti-Mouse CD5-PE (SB Cat. No. 1546-09L) and Rat Anti-Mouse CD3ε-FITC (SB Cat. No. 1535-02).
 
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References
1. Koneru M, Schaer D, Monu N, Ayala A, Frey AB. Defective proximal TCR signaling inhibits CD8+ tumor-infiltrating lymphocyte lytic function. J Immunol. 2005;174:1830-40. (FC)