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Rat Anti-Mouse CD5-BIOT (4H8E5)

Cat. No.:
1546-08
Biotin Anti-Mouse CD5 antibody for use in flow cytometry assays.
$250.00
Size Price (USD) Quantity
0.5 mg $250.00
More Information
Clone 4H8E5
Isotype Rat IgG2aκ
Isotype Control Rat IgG2a-BIOT (KLH/G2a-1-1)
Specificity Mouse CD5
Alternative Names Lyt-1, Ly-1, Lymphocyte antigen 1, Ly-12, Ly-A, T1, Tp67
Description CD5, also known as Lyt-1, is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B-cell antigen CD72. The frequency of CD5+ B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B-1 cells. Binding of CD5 on the T cell surface can augment alloantigen- or mitogen-induced lymphocyte proliferation and induces increased cytosolic free calcium, IL-2 secretion, and IL-2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T-cell and B-cell receptors.
Conjugate BIOT (Biotin)
Buffer Formulation Phosphate buffered saline containing < 0.1% sodium azide
Clonality Monoclonal
Concentration 0.5 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C
Applications Flow Cytometry – Quality tested 1

RRID Number AB_2794858
Gene ID 12507 (Mouse)
Gene ID Symbol Cd5 (Mouse)
Gene ID Aliases Ly-1; Ly-12; Ly-A; Lyt-1
UniProt ID P13379 (Mouse)
UniProt Name CD5_MOUSE (Mouse)

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  1. 1. Koneru M, Schaer D, Monu N, Ayala A, Frey AB. Defective proximal TCR signaling inhibits CD8+ tumor-infiltrating lymphocyte lytic function. J Immunol. 2005;174:1830-40. (FC)