Mouse Anti-Human IL-33-BIOT (SB127j)
Biotin Anti-Human IL-33 antibody for use in ELISA assays.
|Isotype||Mouse (BALB/c) IgG2aκ|
|Isotype Control||Mouse IgG2a-BIOT (HOPC-1)|
|Alternative Names||Interleukin-33, IL-1F11, NF-HEV|
|Description||Interleukin-33 (IL-33), also known as NF-HEV, is a 30 kDa protein and a member of the IL-1 family. This pro-inflammatory cytokine is produced by a variety of cells but is primarily expressed by endothelial and smooth muscle cells in the vasculature and airways. IL-33 binds to the ST2 receptor on target cells which results in the activation of multiple signaling pathways including NF-κB and MAP kinases. Studies have shown that IL-33 promotes T helper type 2 (Th2) cell-mediated immune responses and upregulates production of Th2 associated cytokines including IL-4, IL-5, and IL-13. In vivo administration of this cytokine in mice results in eosinophilia and splenomegaly as well as induced severe pathological changes in the lungs, gastrointestinal tract, and other mucosal organs.|
|Immunogen||E. coli-expressed human IL-33|
|Buffer Formulation||Phosphate buffered saline containing < 0.1% sodium azide|
ELISA – Quality tested|
Note – May be paired with the biotinylated clone SB127c (SB Cat. No. 15700-08) in a sandwich ELISA
|Gene ID Symbol||
|Gene ID Aliases||C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV|
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