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Rat Anti-Human Caspase-2-UNLB (SB123a)

Cat. No.:
17100-01
Purified Anti-Human Caspase-2 antibody for use in western blot assays.
$200.00
Size Price (USD) Quantity
0.1 mg $200.00
More Information
Clone SB123a
Isotype Rat (Sprague Dawley) IgMκ
Isotype Control Rat IgM-UNLB (NIP/M-2)
Specificity Human caspase-2
Alternative Names Nedd2, ICH-1, CASP2
Description The caspases are a family of cysteine proteases that induce apoptosis in response to a variety of intra- and extracellular stimuli. These enzymes are synthesized as inactive precursors which become cleaved at aspartate-specific sites upon induction of apoptosis. Caspase-2 is an initiator caspase that is prevalent in both the cytosol and nucleus in many cell types. During embryonic development it is expressed at relatively high levels in the central nervous system, liver, kidney, and lungs and is prevalent in numerous tissues in adults. Studies have shown that caspase-2 becomes activated in response to several lethal stimuli including DNA damage, ER stress, and death receptor stimulation and further evidence has suggested a role in reactive oxygen species-induced cell death.

The SB123a monoclonal antibody detects bands at ~40 and ~48 kDa corresponding to cleaved and uncleaved forms of caspase-2, respectively.
Immunogen Purified native human caspase-2
Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Clonality Monoclonal
Concentration 1.0 mg/mL
Volume 0.1 mL
Recommended Storage 2-8°C
Applications Western Blot – Quality tested

RRID Number AB_2795175
Gene ID 835 (Human)
Gene ID Symbol CASP2 (Human)
Gene ID Aliases CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57
UniProt ID P42575 (Human)
UniProt Name CASP2_HUMAN (Human)

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