Mouse Anti-Human GSK-3β-HRP (3A11)
Cat. No.:
10920-05
HRP Anti-GSK-3β antibody for use in ELISA and western blot assays.
$396.00
Clone | 3A11 |
---|---|
Isotype | Mouse (BALB/c) IgG2aκ |
Isotype Control | Mouse IgG2a-HRP (HOPC-1) |
Specificity | Human GSK-3β |
Alternative Names | Glycogen synthase kinase-3 beta |
Description | Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3α and GSK-3β. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics, and cell motility. |
Immunogen | Recombinant N-terminal GSK-3β |
Conjugate | HRP (Horseradish Peroxidase) |
Buffer Formulation | 50% Glycerol/50% Phosphate buffered saline, pH 7.4 |
Clonality | Monoclonal |
Concentration | Lot specific |
Volume | 1.0 mL |
Recommended Storage | 2-8°C |
Applications |
ELISA – Quality tested Immunoblotiing – Reported in literature 1 |
RRID Number | AB_2794549 |
Gene ID |
2932 (Human) |
Gene ID Symbol |
GSK3B (Human) |
UniProt ID |
P49841 (Human) |
UniProt Name |
GSK3B_HUMAN (Human) |
Documentation
Certificate of Analysis Lookup
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- 1. Sun M, Song L, Li Y, Zhou T, Jope RS. Identification of an antiapoptotic protein complex at death receptors. Cell Death Differ. 2008;15:1887-1900. (WB)