Hamster Anti-Mouse CD30-UNLB

Cat. No.
1620-01  
Size
0.5 mg  
Price (USD)
$192.00 
Clone mCD30.1
Isotype Hamster (Armenian) IgG1
Isotype Control Hamster IgG-UNLB
Immunogen Mouse CD30-mouse IgG1 fusion protein
Specificity Mouse CD30
Alternalte Name(s) Ki-1, Ber-H2
Description CD30 is a type I transmembrane protein and a member of the tumor necrosis factor receptor superfamily of proteins. Murine CD30 is expressed predominantly in the thymus and it is inducible in mouse splenocytes stimulated with pokeweed mitogen or concanavalin A. In anti-CD3ε-activated spleen cells, CD30 is expressed primarily on the surface of CD8+ T cells with peak expression on days 4 and 5. Stimulation of CD30+ CTL lines with plate-bound anti-CD30 directly signals IL-5 but not IFN-γ production. While these studies demonstrate that CD30 directs cytokine secretion and suggest that CD30 may play a pivotal role in the pattern of cytokine production by T cells, the precise roles of CD30 and its ligand (CD153) in T-cell development have not been clearly defined.
Format/Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Concentration 0.5 mg/mL
Volume 1.0 mL
Storage & Handling 2-8°C
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
Flow Cytometry – Quality tested 1
Stimulation – Reported in literature 1,2
Costimulation – Reported in literature 1
Blocking – Reported in literature 3
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2795037
Gene ID
21941 (Mouse)
Gene Symbol
Tnfrsf8 (Mouse)
Gene Aliases Ki; Cd30; Ki-1; D1S166E
Uniprot ID
Q60846 (Mouse)
Uniprot Name
  • NIH/Swiss mouse fibroblast cell line 3T3 and mCD30-Ig transfected 3T3 cells were stained with Hamster Anti-Mouse CD30-PE (SB Cat. No. 1620-09L).

NIH/Swiss mouse fibroblast cell line 3T3 and mCD30-Ig transfected 3T3 cells were stained with Hamster Anti-Mouse CD30-PE (SB Cat. No. 1620-09L).
 
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References
1. Bowen MA, Lee RK, Miragliotta G, Nam SY, Podack ER. Structure and expression of murine CD30 and its role in cytokine production. J Immunol. 1996;156:442-9. (Immunogen, FC, Stim, Costim)
2. Sun X, Yamada H, Shibata K, Muta H, Tani K, Podack ER, et al. CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice. J Immunol. 2010;185:2222-30. (Stim)
3. Polte T, Behrendt A, Hansen G. Direct evidence for a critical role of CD30 in the development of allergic asthma. J Allergy Clin Immunol. 2006;118:942-8. (Block)