Mouse Anti-Mouse Ly-49F-LE/AF

Cat. No.
1803-14  
Size
0.5 mg  
Price (USD)
$305.00 
Clone HBF-719
Isotype Mouse (BALB/c) IgG1κ
Isotype Control Mouse IgG1-LE/AF
Immunogen CHO-K1 cells transfected with B6 allele of Ly49F gene
Specificity Mouse Ly-49F
Alternalte Name(s) Ly-49
Description The monoclonal antibody HBF-719 reacts with the B6 allele of Ly49F, a member of the lectin-like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells while allowing them to attack infected or transformed cells in which class I molecules have been downregulated. These inhibitory receptors are also expressed on subpopulations of mouse CD8+ T cells. The HBF-719 antibody stains ~11% of NK1.1+CD3- splenocytes, and 3.5% (2.5 month old) to 10.0% (11 month old) of CD8+ spleen cells from C57BL/6 mice.
Format/Conjugate LE/AF (Low Endotoxin/Azide Free)
Buffer Formulation Phosphate buffered saline, pH 7.4
Concentration 0.5 mg/mL
Volume 1.0 mL
Storage & Handling -20°C
Please refer to product specific SDS
Applications
Applications for relevant formats of this clone include -
Flow Cytometry – Quality tested 1,2
Recommended Dilutions Please refer to product specific Technical Bulletin
RRID AB_2795339
Gene ID
16637 (Mouse)
Gene Symbol
Klra6 (Mouse)
Gene Aliases Ly49f; ly-49f
Uniprot ID
Q60653 (Mouse)
Uniprot Name
  • C57BL/6 mouse splenocytes were stained with Mouse Anti-Mouse Ly-49F-PE (SB Cat. No. 1803-09) and Mouse Anti-Mouse NK1.1-FITC (SB Cat. No. 1805-02).

C57BL/6 mouse splenocytes were stained with Mouse Anti-Mouse Ly-49F-PE (SB Cat. No. 1803-09) and Mouse Anti-Mouse NK1.1-FITC (SB Cat. No. 1805-02).
 
Related Products (1)
References
1. Coles MC, McMahon CW, Takizawa H, Raulet DH. Memory CD8 T lymphocytes express inhibitory MHC-specific Ly49 receptors. Eur J Immunol. 2000;30:236-44. (Immunogen, FC)
2. Denning TL, Granger S, Mucida D, Graddy R, Leclercq G, Zhang W, et al. Mouse TCRαβ+CD8αα intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses. J Immunol. 2007;178:4230-9. (FC)