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Mouse Anti-Mouse Ly-49F-BIOT (HBF-719)

Cat. No.:
Biotin Anti-Mouse Ly-49F antibody for use in flow cytometry assays.
Size Price (USD) Quantity
0.5 mg $330.00
More Information
Clone HBF-719
Isotype Mouse (BALB/c) IgG1κ
Isotype Control Mouse IgG1-BIOT (15H6)
Specificity Mouse Ly-49F
Alternative Names Ly-49
Description The monoclonal antibody HBF-719 reacts with the B6 allele of Ly49F, a member of the lectin-like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells while allowing them to attack infected or transformed cells in which class I molecules have been downregulated. These inhibitory receptors are also expressed on subpopulations of mouse CD8+ T cells. The HBF-719 antibody stains ~11% of NK1.1+CD3- splenocytes, and 3.5% (2.5 month old) to 10.0% (11 month old) of CD8+ spleen cells from C57BL/6 mice.
Immunogen CHO-K1 cells transfected with B6 allele of Ly49F gene
Conjugate BIOT (Biotin)
Buffer Formulation Phosphate buffered saline containing < 0.1% sodium azide
Clonality Monoclonal
Concentration 0.5 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C
Applications Flow Cytometry – Quality tested 1,2

RRID Number AB_2795337
Gene ID 16637 (Mouse)
Gene ID Symbol Klra6 (Mouse)
Gene ID Aliases Ly49f; ly-49f
UniProt ID Q60653 (Mouse
UniProt Name KLRA6_MOUSE (Mouse)

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  1. 1. Coles MC, McMahon CW, Takizawa H, Raulet DH. Memory CD8 T lymphocytes express inhibitory MHC-specific Ly49 receptors. Eur J Immunol. 2000;30:236-44. (Immunogen, FC)
  2. 2. Denning TL, Granger S, Mucida D, Graddy R, Leclercq G, Zhang W, et al. Mouse TCRαβ+CD8αα intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses. J Immunol. 2007;178:4230-9. (FC)