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Mouse Anti-Mouse CD72.1-BIOT (10.1.D2)

Cat. No.:
Biotin Anti-Mouse CD72.1 antibody for use in flow cytometry and immunoprecipitation assays.
Size Price (USD) Quantity
0.5 mg $330.00
More Information
Clone 10.1.D2
Isotype Mouse (C57BL/6) IgG2bκ
Isotype Control Mouse IgG2b-BIOT (A-1)
Specificity Mouse CD72.1
Alternative Names Lyb-2.1, CD72a, Lyb-2a
Description Murine CD72.1 (Lyb-2.1), a type II integral membrane glycoprotein and a member of the C-lectin family of cell surface receptors, is a differentiation antigen of B cells and is found in mouse strains expressing the Lyb-2.1 allotype. CD72.1 is the ligand of CD5 which is distributed on all T cells and a small number of B cells. The 10.1.D2 monoclonal antibody blocks binding of CD5 to CD72 on the B cell surface which leads to inhibition of the positive signal resulting from CD5/CD72 pairing. However, 10.1.D2 can itself trigger a positive signal by binding CD72.
Immunogen DBA/2 mouse spleen cells
Conjugate BIOT (Biotin)
Buffer Formulation Phosphate buffered saline containing < 0.1% sodium azide
Clonality Monoclonal
Concentration 0.5 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C
Applications Flow Cytometry – Quality tested 1,4-6
Immunoprecipitation – Reported in literature 2
Activation – Reported in literature 1
Blocking – Reported in literature 5
Costimulation – Reported in literature 3

RRID Number AB_2795197
Gene ID 12517 (Mouse)
Gene ID Symbol Cd72 (Mouse)
Gene ID Aliases CD72c; Ly-19; Ly-32; Lyb-2; Ly-m19
UniProt ID P21855 (Mouse)
UniProt Name CD72_MOUSE (Mouse)

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  1. 1. Subbarao B, Mosier DE. Induction of B lymphocyte proliferation by monoclonal anti-Lyb 2 antibody. J Immunol. 1983;130:2033-7. (Immunogen, FC, Activ)
  2. 2. Robinson WH, Landolfi MM, Schäfer H, Parnes JR. Biochemical identity of the mouse Ly-19.2 and Ly-32.2 alloantigens with the B cell differentiation antigen Lyb-2/CD72. J Immunol. 1993;151:4764-72. (IP)
  3. 3. Snow EC, Mond JJ, Subbarao B. Enhancement by monoclonal anti-Lyb-2 antibody of antigen-specific B lymphocyte expansion stimulated by TNP-Ficoll and T lymphocyte-derived factors. J Immunol. 1986;137:1793-6. (Costim)
  4. 4. Robinson WH, Ying H, Miceli MC, Parnes JR. Extensive polymorphism in the extracellular domain of the mouse B cell differentiation antigen Lyb-2/CD72. J Immunol. 1992;149:880-6. (FC)
  5. 5. Luo W, van de Velde H, von Hoegen I, Parnes JR, Thielemans K. Ly-1 (CD5), a membrane glycoprotein of mouse T lymphocytes and a subset of B cells, is a natural ligand of the B cell surface protein Lyb-2 (CD72). J Immunol. 1992;148:1630-4. (Block, FC)
  6. 6. Zhu Z, Li R, Li H, Zhou T, Davis RS. FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling. Proc Natl Acad Sci USA. 2013;110:E1282-90. (FC)
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