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Mouse Anti-Human FADD-UNLB (1A11)

Cat. No.:
10941-01
Purified Anti-Human FADD antibody for use in ELISA, western blot, and immunoprecipitation assays.
$215.00
Size Price (USD) Quantity
0.1 mg $215.00
More Information
Clone 1A11
Isotype Mouse (BALB/c) IgG1κ
Isotype Control Mouse IgG1-UNLB (15H6)
Specificity Human FADD
Alternative Names FAS-associated death domain protein, GIG3, MGC8528, MORT1
Description Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1β-converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation.
Immunogen Recombinant FADD
Conjugate UNLB (Unconjugated)
Buffer Formulation Borate buffered saline, pH 8.2
Clonality Monoclonal
Concentration 0.5 mg/mL
Volume 0.2 mL
Recommended Storage 2-8°C
Applications ELISA – Quality tested
Western Blot – Quality tested
Immunoprecipitation – Quality tested

RRID Number AB_2794559
Gene ID 8772 (Human)
Gene ID Symbol FADD (Human)
Gene ID Aliases GIG3; MORT1
UniProt ID Q13158 (Human)
UniProt Name FADD_HUMAN (Human)

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