Rat Anti-Mouse CD5-SPRD (4H8E5)
PE/CY5 (SPRD) Anti-Mouse CD5 antibody for use in flow cytometry assays.
|Isotype Control||Rat IgG2a-SPRD (KLH/G2a-1-1)|
|Alternative Names||Lyt-1, Ly-1, Lymphocyte antigen 1, Ly-12, Ly-A, T1, Tp67|
|Description||CD5, also known as Lyt-1, is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B-cell antigen CD72. The frequency of CD5+ B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B-1 cells. Binding of CD5 on the T cell surface can augment alloantigen- or mitogen-induced lymphocyte proliferation and induces increased cytosolic free calcium, IL-2 secretion, and IL-2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T-cell and B-cell receptors.|
|Conjugate||SPRD (R-phycoerythrin/Cyanine 5)|
|Buffer Formulation||Phosphate buffered saline containing < 0.1% sodium azide and a stabilizer|
|Recommended Storage||2-8°C; Avoid exposure to light; Do not freeze|
Spectral Red® is a registered trademark of Southern Biotechnology Associates, Inc.
Spectral Red® is a PE/CY5 tandem conjugate
Cy® is a registered trademark of Global Life Sciences Solutions Germany GmbH
Flow Cytometry – Quality tested 1|
|Gene ID Symbol||
|Gene ID Aliases||Ly-1; Ly-12; Ly-A; Lyt-1|
- 1. Koneru M, Schaer D, Monu N, Ayala A, Frey AB. Defective proximal TCR signaling inhibits CD8+ tumor-infiltrating lymphocyte lytic function. J Immunol. 2005;174:1830-40. (FC)