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Hamster Anti-Mouse Ly-49C/F/H/I-BIOT (14B11)

Cat. No.:
1801-08
Biotin Anti-Mouse Ly-49C/F/H/I antibody for use in flow cytometry assays.
$245.00
Size Price (USD) Quantity
0.5 mg $245.00
More Information
Clone 14B11
Isotype Hamster (Syrian) IgG1
Isotype Control Hamster IgG-BIOT
Specificity Mouse Ly-49C/F/H/I
Alternative Names Ly-49
Description The monoclonal antibody 14B11 reacts with murine Ly49C, Ly49F, Ly49H, and Ly49I, members of the lectin-like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells while allowing them to attack infected or transformed cells in which class I molecules have been downregulated. These inhibitory receptors are also expressed on a subpopulation of mouse CD8+ T cells. The 14B11 antibody stains ~90% of NK1.1+CD3- splenocytes and ~6% of CD8+ spleen cells from C57BL/6 mice. The antibody also stains 30-80% of NK1.1+CD3- splenocytes in other mouse strains tested (BALB/c, C3H, 129, SJL, AKR/J).
Immunogen IL-2 activated natural killed (A-LAK) cells from C57BL/6 mice
Conjugate BIOT (Biotin)
Buffer Formulation Phosphate buffered saline containing < 0.1% sodium azide
Clonality Monoclonal
Concentration 0.5 mg/mL
Volume 1.0 mL
Recommended Storage 2-8°C
Applications Flow Cytometry – Quality tested 1,2
Cytoxicity – Reported in literature 1

RRID Number AB_2795329
Gene ID 16634 (Mouse)
16637 (Mouse)
16639 (Mouse)
16640 (Mouse)
Gene ID Symbol Klra3 (Mouse)
Klra6 (Mouse)
Klra8 (Mouse)
Klra9 (Mouse)
Gene ID Aliases 5E6; Ly49c; NK-2.1; Nk-2; Nk2; Nk2.1; Ly49f; ly-49f; Cmv-1; Cmv1; Ly49h; Ly49u<129>; LY49I1; Ly49I
UniProt ID Q64329 (Mouse)
Q60653 (Mouse)
Q60682 (Mouse)
Q2TJJ8 (Mouse)
UniProt Name KLRA3_MOUSE (Mouse)
KLRA6_MOUSE (Mouse)
KLRA8_MOUSE (Mouse)
Q2TJJ8_MOUSE (Mouse)

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  1. 1. Corral L, Takizawa H, Hanke T, Jamieson AM, Raulet DH. A new monoclonal antibody reactive with several Ly49 NK cell receptors mediates redirected lysis of target cells. Hybridoma. 1999;18:359-66. (Immunogen, Cyto, FC)
  2. 2. Chung JW, Kim MS, Piao Z, Jeong M, Yoon SR, Shin N, et al. Osteopontin promotes the development of natural killer cells from hematopoietic stem cells. Stem Cells. 2008;26:2114-23. (FC)